Published in Clinical Cancer Research, the study reveals that 47% of tumors treated with Aliya PEF developed tertiary lymphoid structures with germinal centers, compared to just 24% in non-ablated control groups. These structures act as local hubs for immune activity, signaling a more complex biological reaction than traditional cell death. Tullia C. Bruno, Ph.D., who led the analysis, noted that this maturation process suggests the technology could eventually serve as a complement to existing immunotherapies.
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Galvanize Therapeutics Study Links Aliya PEF to Immune Activation
Nearly half of non-small cell lung cancer tumors treated with Galvanize Therapeutics' pulsed electric field technology developed mature immune structures, according to new clinical data. The findings suggest that the Aliya PEF system may trigger a sophisticated immune response beyond simple tissue ablation in human patients.
This clinical evidence is supported by an independent review in Nature Cancer, which highlights Aliya PEF as one of the few medical approaches capable of inducing these specific immune structures. William Krimsky, Chief Medical Officer at Galvanize, emphasized that the post-ablation environment is becoming as critical to patient outcomes as the initial procedure itself. The company plans to present the Aliya EX generator and these findings at the American Association for Bronchology and Interventional Pulmonology conference in Denver this week.
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